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"Neonates"

Original Articles

[English]
Effect of Nutritional Support on Postoperative Growth Velocity of Neonates in Neonatal Intensive Care Unit
Hee-In Jo, Ji-Young Sul, Jun-Beom Park
Adv Pediatr Surg 2018;24(2):51-59.   Published online December 9, 2018
DOI: https://doi.org/10.13029/aps.2018.24.2.51
Purpose

This study aimed to evaluate the relationship between nutritional support and growth velocity after abdominal surgery in neonates.

Methods

The electronic medical records of 45 neonates who underwent abdominal surgery in neonatal intensive care unit from 2012 to 2016 were collected to see how surgery and postoperative nutrition affect for the growth of neonate with abdominal surgery. The growth velocity was measured from the time of surgery to the time of discharge based on body weight.

Results

In neonates who achieve their protein requirement on the first day after surgery, the growth velocity was better than that in neonates who did not achieve their protein requirement on the first day after surgery (4.31 vs. 15.21; p=0.004). Based on the type of surgery, length of bowel resection and surgical complications, this study showed better growth velocity in neonates who had no surgical complications (5.34 vs. 12.74; p=0.775), reoperation (5.25 vs. 22.19, p=0.987), or bowel resection (6.79 vs. 9.95, p=0.302). However, there was no statistically significant difference among these factors.

Conclusion

We concluded in this study that adequate protein supplement from the first day of surgery could have a positive effect on the growth velocity of neonates who underwent abdominal surgery.

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[English]
Total Parenteral Nutrition (TPN) via Peripheral Veins in Neonatal Surgical Patients
Jong In Lee, Poong Man Jung
J Korean Assoc Pediatr Surg 1998;4(1):16-26.   Published online June 30, 1998
DOI: https://doi.org/10.13029/jkaps.1998.4.1.16

Parenteral nutntlon has been an essential part of postoperative care of neonates requiring major surgery who are unable to tolerate enteral feeding for long periods during the postoperative period. However, TPN via central venous catheters(central TPN), used in increasing trend, still presents significant morbidity. To find out whether TPN via peripheral veins(peripheral TPN) could be used as a viable alternative for postoperative parenteral nutrition in neonates, a clinical study was carried out by a retrospective analysis of 53 neonates subjected to peripheral TPN for more than 7 days after surgery. Operations consisted of procedures for esophageal atresia with tracheoesophageal fistula, gastroschisis and omphalocele. Surgery was performed at the Division of Pediatric Surgery, Department of Surgery, Hanyang University Hospitall, from 1983 to 1994. The mean total duration of TPN was 13.3 days (range; 7-58 days), the average daily total fluid intake was 117.6 ml/kg during TPN and 158.6 ml/kg during subsequent oral feeding. The average daily total calorie intake was 57.7 kcal/kg during full strength TPN and 101.3 kcal/kg during subsequent oral feeding. The mean urine output was maintained at 3.5 ml/kg/hour during TPN and at 3.6 ml/kg/hour during subsequent oral feeding. The increment of body weight observed during TPN was 132g in TEF, 53g in gastroschisis and 3g in omphalocele patients, while loss of body weight was not observed. The mortality rate was 5.7%(3/53) and was related to the underlying congenital anomalies, not the TPN. The most common complication of peripheral TPN observed was laboratory findings suggestive of liver dysfunction in 23 cases( 43.4%) with no significant clinical symptom or signs in any case, transient pulmonary edema in one case, and generalized edema in one case. None of the major complications usually expected associated with central TPN were observed. The result of this study suggest that peripheral TPN can be used for adeguate postoperative nutritional support in neonates requiring 2 to 3 weeks of TPN.

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Case Report

[English]
Primary Segmental Volvulus of the Small Bowel: Report of 2 Cases
Myung Duk Lee
J Korean Assoc Pediatr Surg 1996;2(1):46-52.   Published online June 30, 1996
DOI: https://doi.org/10.13029/jkaps.1996.2.1.46

Primary segmental volvulus of the small intestine is not associated with malrotation, malfixation of the midgut, nor other primary small bowel lesions such as small bowel tumors. This entity is known to be more prevalent in adult and in certain global areas associated with particular diet habits. There have been very few reports in neonates, but not in this country so far. The author reports two cases of primary segmental volvulus. Case 1 was a septic 4-day-old girl with hematochezia due to jejunal volvulus with partial necrosis and panperitonitis. Resection of the segment and Bishop-Koop enterostomy were successful. Case 2 was a 3-day-old boy, who had ileal volvulus with ultra-short length of ileal atresia, probably due to intrauterine segmental volvulus. Limited resection of the atresia and spreading of the mesenteric base were enough to recovery. The rarity of the pathognomonic findings and limitation of the diagnostic workup due to rapid prqgression limit early diagnosis and good survival rate in this particular condition.

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Original Article

[English]
To investigate the diagnostic accuracy and applicability of barium enema (BE) and rectal suction biopsy with acetyl cholinesterase (AChE) histochemistry in the diagnosis of neonatal Hirschsprung's disease (HD), we retrospectively reviewed the findings of BE and AChE staining in 96 neonates with suspected HD during a 10-year period from January 1991 to December 2000. Sixty-nine cases of HD (58 males and 11 females) and 27 cases of non-HD are included in this study. In regard to BE, HD was based on definite transitional zone, suspicious HD on reversed rectosigmoid index (RSI <1), and non-HD on normal RSI (RSI>1). The histochemical criterion used for the diagnosis of HD was that of Chow et al (1977), i.e., the presence of many coarse discrete cholinergic nerve fibers in the muscularis mucosae and in the immediately subjacent submucosa regardless of infiltration of cholinergic nerve fibers in the lamina propria. Of 66 neonates with HD who underwent BE, transitional zone was identified in 33 cases (50%) and reversed RSI in 19 cases (21%), microcolon in 4 cases and normal finding in 10 cases (15%) while of 27 neonates with non-HD, there was normal finding in 16 cases and reversed RSI in 9 cases (41%). Thus diagnostic accuracy based on transitional zone was 64%. The positive predictive value of reversed RSI for the diagnosis of HD was 68%. Of 42 neonates with HD who underwent AChE histochemistry, there were 41 AChE-positive reactions and one AChE-negative reaction in a neonate with total colonic aganglionosis, while of 27 cases of non-HD, there were one equivocal AChE-positive reaction and 26 AChE-negative reactions. Thus AChE histochemical study showed a 97% diagnostic accuracy with a 98% sensitivity and a 96% specificity. In conclusion, we believe that BE is valuable as a first diagnostic step since about 80% of neonates with HD show significant radiologic findings such as a transitional zone or reversed RSI. AChE histochemical study was a more reliable diagnostic tool showing a 97% diagnostic accuracy, and is particularly valuable in neonates with HD who showed reversed RSI or normal RSI on BE. A diagnostic algorithm in neonates with suspicious HD was proposed.particularly valuable in neonates with HD who showed reversed RSI or normal RSI on BE. A diagnostic algorithm in neonates with suspicious HD was proposed.
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