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Original Article

Clinical Feature of Neonatal Neuroblastoma: Comparison of Outcome between Diagnosed Prenatally and at Postpartum Group

Hwon Ham Park1, Soo-Hong Kim4, Sung-Eun Jung1, Seong-Cheol Lee1, Kwi-Won Park1, Ji Won Lee2, Hyoung Jin Kang2, Hee Young Shin2, Hae Woon Baek3, Hyun-Young Kim1
Journal of the Korean Association of Pediatric Surgeons 2014;20(2):53-57.
Published online: December 30, 2014

1Department of Pediatric Surgery, Seoul National University Children's Hospital, Seoul, Korea.

2Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

3Department of Pathology, Seoul National University Children's Hospital, Seoul, Korea.

4Department of Pediatric Surgery, Pusan National University Children's Hospital, Yangsan, Korea.

Correspondence: Hyun-Young Kim. Department of Pediatric Surgery, Seoul National University Children's Hospital, 101, Daehak-ro, Jongno-gu, Seoul 110-744, Korea. Tel: +82-2-2072-2478, Fax: +82-2-747-5130, spkhy02@snu.ac.kr
• Received: October 16, 2014   • Revised: November 3, 2014   • Accepted: November 4, 2014

Copyright © 2014 by the Korean Association of Pediatric Surgeons

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Purpose
    Neonatal neuroblastoma (NBL) is the most common malignant tumor in neonates, but there have been few studies about it. The purpose of this study was to investigate the clinical features of NBL and to compare prenatal and postnatal diagnosed groups.
  • Methods
    Nineteen patients who were diagnosed with NBL prenatally or within 28 days after birth from February 1986 to February 2013 in Seoul National University Hospital were enrolled in the study. The patients were categorized according to the International Neuroblastoma Staging System (INSS) and Children's Oncology Group (COG). Retrospective medical-record reviews were performed on these patients. The operative date, complication, pathological stage, and overall survival of the prenatally diagnosed group and the postpartum diagnosed group were compared.
  • Results
    Tumor was detected via prenatal ultrasonography in 8 patients (42.1%), and 11 patients (57.9%) were diagnosed within 28 days after birth. Based on INSS, the patients were divided into the stage I (n=8), stage II (n=1), stage III (n=3), stage IV (n=4), and stage IVs (n=3) groups, respectively. Based on COG, on the other hand, the patients were divided into the low-risk (n=8), intermediate-risk (n=8), and high-risk (n=3) groups. The postoperative complication rate was 29%. One patient died from complications from chemotherapy. The other 18 patients' mean follow-up period was 77.7 months. The differences between the postoperative complication rate, proportion of early-stage tumor, and overall survival of the prenatal and postnatal groups were not statistically significant (p=0.446, p=0.607, p=0.414).
  • Conclusion
    NBL showed favorable outcomes but relatively higher postoperative complications. There seem to be no significant statistical differences in the postoperative complications, proportion of early-stage tumor, and overall survival between the prenatally diagnosed group and the postpartum diagnosed group.
  • Keywords: Neuroblastoma; Neonate; Prenatal diagnosis; Postpartum; Outcome

No potential conflict of interest relevant to this article was reported.

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Table 1
Patient Demographics

M, male; F, female; AG, adrenal gland; Pre/postop., pre/postoperative; Rt., right; Lt., left.

a)Stage according to the International Neuroblastoma Staging System. b)Risk according to the Children's Oncology Group.

c)Complete resection of primary site.

jkaps-20-53-i001.jpg
Table 2
Outcome of Prenatally Diagnosed Group and Diagnosed at Postpartum Group
jkaps-20-53-i002.jpg

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Clinical Feature of Neonatal Neuroblastoma: Comparison of Outcome between Diagnosed Prenatally and at Postpartum Group
J Korean Assoc Pediatr Surg. 2014;20(2):53-57.   Published online December 30, 2014
DOI: https://doi.org/10.13029/jkaps.2014.20.2.53
Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
Format:
Include:
Clinical Feature of Neonatal Neuroblastoma: Comparison of Outcome between Diagnosed Prenatally and at Postpartum Group
J Korean Assoc Pediatr Surg. 2014;20(2):53-57.   Published online December 30, 2014
DOI: https://doi.org/10.13029/jkaps.2014.20.2.53
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Clinical Feature of Neonatal Neuroblastoma: Comparison of Outcome between Diagnosed Prenatally and at Postpartum Group
Clinical Feature of Neonatal Neuroblastoma: Comparison of Outcome between Diagnosed Prenatally and at Postpartum Group

Patient Demographics

M, male; F, female; AG, adrenal gland; Pre/postop., pre/postoperative; Rt., right; Lt., left.

a)Stage according to the International Neuroblastoma Staging System. b)Risk according to the Children's Oncology Group.

c)Complete resection of primary site.

Outcome of Prenatally Diagnosed Group and Diagnosed at Postpartum Group

Table 1 Patient Demographics

M, male; F, female; AG, adrenal gland; Pre/postop., pre/postoperative; Rt., right; Lt., left.

a)Stage according to the International Neuroblastoma Staging System. b)Risk according to the Children's Oncology Group.

c)Complete resection of primary site.

Table 2 Outcome of Prenatally Diagnosed Group and Diagnosed at Postpartum Group

Table 1

Table 2

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