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Case Report

A Case of Pediatric Nodal Marginal Zone Lymphoma

Byunghun Min, Joong Kee Youn, Ji-Won Han, Chaeyoun Oh, Hyun-Young Kim, Sung-Eun Jung
Journal of the Korean Association of Pediatric Surgeons 2016;22(2):59-62.
Published online: December 22, 2016

Department of Pediatric Surgery, Seoul National University Children’s Hospital, Seoul, Korea

Correspondence: Hyun-Young Kim, Department of Pediatric Surgery, Seoul National University Children’s Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea. Tel: +82-2-2072-2478, Fax: +82-2-747-5130, E-mail: spkhy02@snu.ac.kr
• Received: July 21, 2016   • Revised: October 18, 2016   • Accepted: October 18, 2016

Copyright © 2016 Korean Association of Pediatric Surgeons

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Lymph node enlargement is a common finding in children suggesting normal or benign. Palpable nodes which are large, hard or fixed must be examined carefully to rule out malignant diseases. In this case, a 15-year-old boy presented to our hospital to inspect the palpable mass at his post-auricular area being found 2 months ago. It was diagnosed as nodal marginal zone lymphoma (NMZL) through excisional biopsy and immunohistochemistry. NMZL is very rare, especially in children and young adults, but occurs locally in most cases with a good prognosis compared to adults. We described a rare case of NMZL diagnosed in adolescent.
  • Keywords: Lymphoma; Nodal marginal zone lymphoma; Pediatric; Malignant lymphoma; Lymphadenopathy
Fig. 1.
A palpable, fixed 3×2-cm-sized mass positioning at the left posterior auricular area (arrowheads).
jkaps-2016-22-2-59f1.jpg
Fig. 2.
Ultrasonographic image showing a hypoechoic lobulated mass, with 2.2×2.4×0.8 cm size and inner vascularity (arrowheads).
jkaps-2016-22-2-59f2.jpg
Fig. 3.
Immunophenotypic features of excised mass. (A) H&E stain (×40) showing a gross lymphoid tissue with effaced normal follicular architectures suggesting neoplastic rather than reactive condition. (B) With a few normal germinal centers left, it was mostly filled with diffusely grown small to medium-sized atypical cells (H&E stain, ×200). These cells were positive in CD20 (B lymphocyte antigen; C) and Bcl-2 (F) but negative in CD10 (D) and Bcl-6 (E) (C-F: ×40).
jkaps-2016-22-2-59f3.jpg
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  • 6. Angelopoulou MK, Kalpadakis C, Pangalis GA, Kyrtsonis MC, Vassilakopoulos TP. Nodal marginal zone lymphoma. Leuk Lymphoma 2014;55:1240-1250.
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  • 8. Petit B, Chaury MP, Le Clorennec C, Jaccard A, Gachard N, Moalic-Judge S, et al. Indolent lymphoplasmacytic and marginal zone B-cell lymphomas: absence of both IRF4 and Ki67 expression identifies a better prognosis subgroup. Haematologica 2005;90:200-206.
  • 9. van den Brand M, van Krieken JH. Recognizing nodal marginal zone lymphoma: recent advances and pitfalls. A systematic review. Haematologica 2013;98:1003-1013.
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A Case of Pediatric Nodal Marginal Zone Lymphoma
J Korean Assoc Pediatr Surg. 2016;22(2):59-62.   Published online December 22, 2016
DOI: https://doi.org/10.13029/jkaps.2016.22.2.59
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A Case of Pediatric Nodal Marginal Zone Lymphoma
J Korean Assoc Pediatr Surg. 2016;22(2):59-62.   Published online December 22, 2016
DOI: https://doi.org/10.13029/jkaps.2016.22.2.59
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A Case of Pediatric Nodal Marginal Zone Lymphoma
Image Image Image
Fig. 1. A palpable, fixed 3×2-cm-sized mass positioning at the left posterior auricular area (arrowheads).
Fig. 2. Ultrasonographic image showing a hypoechoic lobulated mass, with 2.2×2.4×0.8 cm size and inner vascularity (arrowheads).
Fig. 3. Immunophenotypic features of excised mass. (A) H&E stain (×40) showing a gross lymphoid tissue with effaced normal follicular architectures suggesting neoplastic rather than reactive condition. (B) With a few normal germinal centers left, it was mostly filled with diffusely grown small to medium-sized atypical cells (H&E stain, ×200). These cells were positive in CD20 (B lymphocyte antigen; C) and Bcl-2 (F) but negative in CD10 (D) and Bcl-6 (E) (C-F: ×40).

Fig. 1.

Fig. 2.

Fig. 3.

A Case of Pediatric Nodal Marginal Zone Lymphoma
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